There were a few times I came close to loosing, the impish pocket realm and flooding it with deathfog/lava by accident, which would of lost red prince for good; BUT I took the biggest chance I've ever taken and did living on the edge on my player character then went inside, tornado-ed the ground to clear lava/deathfog.
Next was the doctor in arx, had to leave and come back a few times because at the start he casted bad shit on me/bad placement.
Also shadow prince attacking I almost died but I revive hopped behind a door and prepared and downed potions like a mad lad.
I almost lost to the Eternal in the blackpits, I lost like two to three other runs there too, that fight is INSANELY hard.
Alice alison was hard for a mage party but I was able fuck her up after a few tries of running away and coming back.